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Wild Geranium, Cranesbill

Geranium maculatum

Found in rich woods

Wild geraniums are not related to the garden varieties you get at the nursery.

Photo by Karen Bergeron

Next > Wild Ginger
Antiviral Res. 2008 Aug;79(2):114-20. Epub 2008 Apr 7.

In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L.
Li J, Huang H, Feng M, Zhou W, Shi X, Zhou P.

Department of Biosynthetic Medicinal Chemistry, School of Pharmaceutical Sciences, Fudan University, Shanghai 200032, PR China.

Abstract
Natural products provide a large reservoir of potentially active agents with anti-hepatitis B virus (HBV) activity. We examined the effect of the polyphenolic extract from Geranium carolinianum L. (PPGC) on HBV replication both in vitro and in vivo. In the human HBV-transfected liver cell line HepG(2) 2.2.15, PPGC effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC(50) values of 46.85 microg/ml for HBsAg and 65.60 microg/ml for HBeAg at day 9. Consistent with the HBV antigen reduction, PPGC (100 microg/ml) also reduced HBV DNA level by 35.9%. In the duck hepatitis B virus (DHBV) infected ducks, after PPGC was dosed intragastricly (i.g.) once a day for 10 days, the plasma DHBV DNA level was reduced, with an ED(50) value of 47.54 mg/kg. In addition, Southern blot analysis confirmed the in vivo anti-HBV effect of PPGC in ducks and PPGC also reduced the plasma and the liver DHBV DNA level in a dose-dependent manner. Furthermore, significant improvement of the liver was observed after PPGC treatment, as evaluated by the histopathological analysis.
 

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Editor Karen Bergeron
AltNature Herbals  P.O. Box 93 Erin, TN 37061
Please use email for questions about herbs.  Email karen@altnature.com

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 The herbal information on this web site is intended for educational purposes only. It is not the intention of the editor to advise on health care. Please see a medical professional about any health concerns you have.  Disclaimer - These statements have not been evaluated by the FDA.  The information on this web site is not intended to prevent, diagnose, treat, or cure any disease.

This information is intended as an introduction to how medicinal herb plants are used. It is intended for educational purposes only. I am not a medical professional and I cannot prescribe what herbs are right for you. I cannot answer medical questions, so please do not ask me (or any other complete stranger for that matter) to prescribe herbal cures, treatment or to guess what is wrong with you.

If you use herbs, do so responsibly. Consult your doctor about your health conditions and use of herbal supplements. Herbs may be harmful if taken for the wrong conditions, used in excessive amounts, combined with prescription drugs or alcohol, or used by persons who don't know what they are doing. Just because an herbal remedy is natural, does not mean it is safe! There are herbs that are poisonous such as Poison Hemlock, Jimson weed, and many more.

I will be happy to help you ID wild plants that you find, or help you locate herbs, plants or herb seeds and especially pictures.
email karen@altnature.com

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